A copper‐catalyzed tandem process to generate chiral cyclobutene derivatives has been developed. It is based on an enantioselective conjugate addition or reduction of a cyclobutenone and sequential trapping with a chlorophosphate in a one‐pot process. These phosphates are stable under mildly acidic conditions and serve as good electrophiles in Negishi coupling reactions.
Address: Chemistry Building, Department of Chemistry, Fudan University
2005 Songhu Road, Yangpu District, Shanghai 200438, China Tel: 86-21-31242791
Copyright © Department of chemistry, Fudan University 2014 Support：WeiCheng